3. 大腸癌（Colon Cancer）
動物実験において、ブラックシードのオイルには、マウスの大腸ガンを抑制する効果があり、目に見えるような副作用はなかったことが判明しています。
細かい情報へ
B Chemopreventive potential of volatile
oil from black cumin (Nigella sativa L.) seeds against rat colon
carcinogenesis.
Abstract
Chemopreventive effects of orally administered
Nigella sativa oil on the induction and development of
1,2-dimethylhydrazine-induced aberrant crypt foci (ACF), putative preneoplastic
lesions for colon cancer, were investigated in Fischer 344 rats. Starting at 6
wk of age, 45 male rats (groups 1-3) were subcutaneously injected with DMH once
a week for 3 wk. Group 1 (15 rats) served as a carcinogen control group without
N. sativa administration. Group 2 or 3 (15 rats each) were given the oil in the
postinitiation stage or in the initiation stage, respectively. Animals of group
4 (11 rats) were injected with 0.9% saline and received N. sativa oil from the
beginning until the termination. At sacrifice, 14 wk after the start, the total
numbers of ACF as well as those with at least four crypts were significantly
reduced in group 2 (P < 0.01). However, treatment with N. sativa oil in the
initiation stage (group 3) did not exhibit significant inhibitory effects
except on foci with only one aberrant crypt. Immunohistochemical analysis of
5-bromo-2'.-deoxyuridine labeling in colonic crypts revealed the N. sativa oil
to have significant antiproliferative activity in both initiation and
postinitiation stages and especially in the latter. Histological examination revealed
no pathological changes in the liver, kidneys, spleen, or other organs of rats
treated with N. sativa. In addition, biochemical parameters of blood and urine
as well as body weight gain were not affected. These findings demonstrate that
the volatile oil of N. sativa has the ability to inhibit colon carcinogenesis
of rats in the postinitiation stage, with no evident adverse side effects, and
that the inhibition may be associated, in part, with suppression of cell
proliferation in the colonic mucosa.