鉛から脳損傷(Brain Damage from Lead)
ブラックシードは、鉛の脳内蓄積が原因で起こりうる脳損傷を抑制することが可能です。
Thymoquinone ameliorates lead-induced brain damage in Sprague Dawley rats
Khaled Radada, 1, , , Khaled Hassaneina, 1, Mubarak Al-Shraimb, Rudolf Moldzioc,
Abstract
The present study aims to investigate the
protective effects of thymoquinone, the major active ingredient of Nigella sativa seeds, against lead-induced brain damage
in Sprague-Dawley rats. In which, 40 rats were divided into four groups (10
rats each). The first group served as control. The second, third and fourth
groups received lead acetate, lead acetate and thymoquinone, and thymoquinone
only, respectively, for one month. Lead acetate was given in drinking water at
a concentration of 0.5 g/l (500 ppm). Thymoquinone was given daily at
a dose of 20 mg/kg b.w. in corn oil by gastric tube. Control and
thymoquinone-treated rats showed normal brain histology. Treatment of rats with
lead acetate was shown to produce degeneration of endothelial lining of brain
blood vessels with peri-vascular cuffing of mononuclear cells consistent to
lymphocytes, congestion of choroid plexus blood vessels, ischemic brain
infarction, chromatolysis and neuronal degeneration, microglial reaction and
neuronophagia, degeneration of hippocampal and cerebellar neurons, and axonal
demyelination. On the other hand, co-administration of thymoquinone with lead
acetate markedly decreased the incidence of lead acetate-induced pathological
lesions. Thus the current study shed some light on the beneficial effects of
thymoquinone against neurotoxic effects of lead in rats.
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