Thymoquinone induces apoptosis in oral cancer cells through p38β inhibition.
Abdelfadil E1, Cheng YH, Bau DT, Ting WJ, Chen LM, Hsu HH, Lin YM, Chen RJ, Tsai FJ, Tsai CH, Huang CY.
Oral cancer is a common malignancy associated
with high morbidity and mortality. While p38 MAPK is reported to be involved in
different cellular activities such as proliferation and differentiation,
reports rarely define the roles of the individual members of the p38 MAPK
family in cancer. We used two unique cell lines developed by our lab
representing chemically induced oral cancer cells (T28) and non-tumor cells
(N28) obtained from tissues surrounding the induced cancer as a model to screen
out whether p38 MAPK is involved in the malignant transformation processes. The
results suggest an association between p38β not p38α and oral cancer
development. Additionally, the anti-cancer activity of thymoquinone (TQ) was
screened out and we found evidences suggesting that the anti-tumor activity of
TQ may be attributed to the downregulation of p38β MAPK.